Simple method for the determination of anthelmintic drugs in milk intended for human consumption using liquid chromatography–tandem mass spectrometry

BACKGROUND Helminth infections in animals to be consumed by humans are an important medical and public health problem. Pharmaceutical research has focused on developing new anthelmintic drugs for parasite control these animals. However, the incorrect use of anthelmintics can leave residues animal products intended human consumption. Their determination is therefore crucial terms food safety. RESULTS In this work, a simple sensitive method been developed analysis milk. The involves extraction analytes using QuEChERS (quick, easy, cheap, effective, rugged, safe) method, separation liquid chromatography–tandem mass spectrometry (LC–MS/MS). core-shell column significantly reduced time compared with conventional columns. was validated applied different commercial milk samples: whole, semi-skimmed skimmed cows' milk, goats' None benzimidazoles studied found samples analyzed, so were spiked at three concentration levels (10, 50, 100 ?g kg?1). CONCLUSIONS proposed provided high sensitivity other methods samples, well below established maximum residue limit (MRLs) values. simple, precise, accurate, leads good recovery levels. It used successfully routine analysis. © 2021 Authors. Journal Science Food Agriculture published John Wiley & Sons Ltd behalf Society Chemical Industry.